SPRAVATO® · Esketamine Nasal Therapy
When traditional antidepressants haven't worked. SPRAVATO often does.
FDA-approved for treatment-resistant depression. Administered in our Dixboro Village clinic under direct psychiatric supervision with the continuity of your regular clinician, not a rotating staff.
Coverage details confirmed during your screening call.
From inquiry to your first appointment in 2–3 days.
Inquire
Submit a request below or call (734) 206-2888.
Screening Call
A clinician calls you within 24 business hours to confirm fit.
First Appointment
See Dr. Zubairi within 2–3 days of your inquiry.
Clinical evidence
What the research shows.
52%
Response rate
SPRAVATO + oral antidepressant vs placebo + oral antidepressant in pivotal FDA trials (TRANSFORM-2).
2-4 wks
Time to response
Many patients report meaningful symptom relief within the first weeks of induction faster than oral antidepressants.
70%
Adherence rate
Patients in clinical settings completing the full 8-session induction course in real-world data.
Source: FDA TRANSFORM-2 Phase 3 trial data and SPRAVATO REMS registry. Individual results vary; not all patients respond.
Who SPRAVATO is for — and who it isn't.
SPRAVATO may be a fit if you
- — Have been diagnosed with treatment-resistant depression
- — Have tried two or more antidepressants without adequate relief
- — Are an adult (18 or older)
- — Are medically stable and able to attend in-clinic treatment sessions
- — Can stay in-clinic for ~2 hours per session for monitoring
- — Have a ride home after each session (you cannot drive)
SPRAVATO is not appropriate if you
- — Have certain cardiovascular conditions or uncontrolled high blood pressure
- — Have a history of aneurysm or intracerebral hemorrhage
- — Are pregnant, planning pregnancy, or breastfeeding
- — Have a history of certain substance use disorders
- — Have psychosis as a primary diagnosis
- — Are under 18 (not FDA-approved for minors)
What to expect
What a SPRAVATO session actually looks like.
No surprises. Here's the full 2-hour walkthrough from the moment you arrive to the moment your ride picks you up.
Check in & vitals
You arrive 15 minutes before your session. We check blood pressure, run through any new symptoms, and you settle into your private treatment room.
You administer the nasal spray
Under our supervision, you spray the SPRAVATO device typically 2–3 devices, 5 minutes apart. We're with you the entire time.
Recline. Breathe. Notice.
Most patients feel effects within 10 minutes a sense of lightness, sometimes mild dissociation. We monitor blood pressure 3 to 4 times during your two hours stay.
Your ride takes you home
Once vitals are stable and you're alert, you're discharged. You cannot drive for the rest of the day. Bring a book you'll be relaxed but alert.
The full SPRAVATO course, week by week.
Weeks 1–4 · Induction
Weeks 5–8 · Stabilization
Week 9+ · Maintenance
Why it matters where you go
SPRAVATO under direct psychiatric supervision not at an infusion clinic.
SPRAVATO is medication management.
A SPRAVATO course works best when it's integrated with your full psychiatric care your concurrent antidepressant, your other diagnoses, your therapist, your family circumstances. That requires a psychiatrist who knows you, not a technician administering a substance.
Continuity beats convenience.
At chain SPRAVATO clinics, you may see a different prescriber each visit. Here, Dr. Zubairi or your assigned NP supervises your full course same clinician, every session, with the full picture of your care.
Fast-Track SPRAVATO
Request a Fast-Track SPRAVATO consultation.
Submit your details below. A clinician will call you within 24 business hours to confirm fit. If SPRAVATO is appropriate, you'll see Dr. Zubairi within 2–3 days.
What happens next: A clinician not an admin will call you to understand what you're looking for, review your treatment history, and confirm SPRAVATO is the right next step.
We accept most major insurance plans.
Coverage details confirmed during your screening call.
Request a callback
Tell us a bit about you and we’ll call back within 24 business hours.
TMS or SPRAVATO?
Two interventional options. Which is right for you?
Common questions
SPRAVATO FAQs.
SPRAVATO (esketamine) is the S-enantiomer of ketamine chemically related but distinct. It's the only FDA-approved psychedelic-class medication for treatment-resistant depression. IV ketamine, by contrast, is used off-label for depression. SPRAVATO has the regulatory and insurance pathway; IV ketamine doesn't.
Many patients describe meaningful change between week 2 and week 3 of induction. Some respond faster, some take the full 4 weeks. We assess response on PHQ-9 at every visit so the trajectory is measured, not guessed.
Most patients describe mild dissociation a sense of lightness, distance from worries, sometimes visual softening. It's not euphoria and it's not unpleasant. Effects peak around 30 minutes and resolve within 2 hours. You'll be alert when you leave.
FDA REMS protocol requires no driving for the rest of the day after a SPRAVATO session even though you'll feel alert by the time you leave. Plan a ride for every session. Many patients arrange a rotation with family or use a rideshare credit.
There's no fixed end date. After induction, maintenance schedules vary widely every 2 weeks is common; some taper to every 4 weeks; some discontinue after 6–12 months. We make that decision together based on your response and stability.
Most commercial insurers cover the SPRAVATO drug cost itself for treatment-resistant depression diagnoses. Our clinical fee is out-of-network submit a superbill for OON reimbursement. The manufacturer's CarePath program often reduces drug copay to $0–$10 for eligible patients.
No, SPRAVATO is approved as an add-on to an oral antidepressant, not a replacement. You'll continue your current medication during the course. We may adjust it at follow-up visits based on response.
SPRAVATO is used to treat treatment-resistant depression and major depression with suicidal thoughts.
We provide Spravato treatment at our Ypsilanti office easily accessible from Ann Arbor, Plymouth, Canton, Brighton, Chelsea as well as surrounding areas in Washtenaw, Livingston and Jackson counties.
SPRAVATO is prescribed by a certified healthcare provider after a clinical evaluation. You must meet specific criteria for treatment-resistant depression, and the treatment is administered in a supervised medical setting.
Find out if SPRAVATO is right for you.
Submit a request and a clinician will call within 24 business hours. First appointment with Dr. Zubairi in 2–3 days.